Increased tau protein level in postmortem cerebrospinal fluid

6-acetylmorphine detection in postmortem cerebrospinal fluid.

Opiate testing is one of the most frequently requested assays in the death investigation of suspected drug overdoses. Screening assays typically target morphine, whereas more specific assays are able to positively identify and quantitate the particular opiate present in the specimen. Because many opiates are metabolized to morphine, it is often desirable to differentiate heroin-related deaths f...

Cerebrospinal-fluid tau protein and aspartate aminotransferase in Parkinson's disease.

Tau transgenic mice as models for cerebrospinal fluid tau biomarkers.

Levels of tau in cerebrospinal fluid (CSF) are elevated in Alzheimer's disease (AD) patients. It is believed this elevation is related to the tau pathology and neurodegeneration observed in AD, but not all tauopathies have increased CSF tau. There has been little pre-clinical work to investigate mechanisms of increased CSF tau due to the difficulty in collecting CSF samples from mice, the most ...

Tau protein as a possible marker of cerebrospinal fluid leakage in cerebrospinal fluid rhinorrhoea: A pilot study

INTRODUCTION The management of posttraumatic cerebrospinal fluid (CSF) rhinorrhoea remains a clinical challenge. Cerebrospinal fistula is a dural defect responsible for possible CSF leakage into the contiguous air-filled cavities located at the skull base. The risk of central nervous system infection in these conditions is severe and can be life threatening. Consequently, a specific CSF biomark...

Cerebrospinal fluid Aβ and tau level fluctuation in an older clinical cohort.

OBJECTIVE To determine whether cerebrospinal fluid (CSF) biomarkers for Alzheimer disease fluctuate significantly over time in a cohort of older, mildly symptomatic individuals. DESIGN Biomarker validation in a clinical cohort. SETTING University hospital inpatient unit. PARTICIPANTS Ten patients admitted for CSF drainage for diagnostic purposes. MAIN OUTCOME MEASURES The CSF levels of ...